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Python

# Copyright 2019 Novartis Institutes for BioMedical Research Inc. Licensed
# under the Apache License, Version 2.0 (the "License"); you may not use
# this file except in compliance with the License. You may obtain a copy
# of the License at http://www.apache.org/licenses/LICENSE-2.0. Unless
# required by applicable law or agreed to in writing, software distributed
# under the License is distributed on an "AS IS" BASIS, WITHOUT WARRANTIES
# OR CONDITIONS OF ANY KIND, either express or implied. See the License for
# the specific language governing permissions and limitations under the License.
# import BaseHTTPServer
import json
import logging
import os
import urllib.parse
from threading import Lock, Thread
from flask import (
Flask,
make_response,
redirect,
render_template,
request,
send_from_directory,
url_for,
)
from werkzeug.middleware.proxy_fix import ProxyFix
from cellxgene_gateway import env, flask_util
from cellxgene_gateway.backend_cache import BackendCache
from cellxgene_gateway.cache_entry import CacheEntryStatus
from cellxgene_gateway.cache_key import CacheKey
from cellxgene_gateway.cellxgene_exception import CellxgeneException
from cellxgene_gateway.extra_scripts import get_extra_scripts
from cellxgene_gateway.filecrawl import render_item_source
from cellxgene_gateway.process_exception import ProcessException
from cellxgene_gateway.prune_process_cache import PruneProcessCache
from cellxgene_gateway.util import current_time_stamp
app = Flask(__name__)
item_sources = []
default_item_source = None
# Guard for lazy initialization so tests can import this module without
# triggering environment-dependent side effects. initialize_data_sources()
# will set this to True when it has run.
data_sources_initialized = False
data_sources_init_lock = Lock()
def _force_https(app):
def wrapper(environ, start_response):
if env.external_protocol is not None:
environ["wsgi.url_scheme"] = env.external_protocol
return app(environ, start_response)
return wrapper
def set_no_cache(resp):
resp.headers["Cache-Control"] = "no-cache, no-store, must-revalidate"
resp.headers["Pragma"] = "no-cache"
resp.headers["Expires"] = "0"
resp.headers["Cache-Control"] = "public, max-age=0"
return resp
app.wsgi_app = _force_https(app.wsgi_app)
if (
env.proxy_fix_for > 0
or env.proxy_fix_proto > 0
or env.proxy_fix_host > 0
or env.proxy_fix_port > 0
or env.proxy_fix_prefix > 0
):
app.wsgi_app = ProxyFix(
app.wsgi_app,
x_for=env.proxy_fix_for,
x_proto=env.proxy_fix_proto,
x_host=env.proxy_fix_host,
x_port=env.proxy_fix_port,
x_prefix=env.proxy_fix_prefix,
)
# WSGI middleware to ensure data sources are initialized before the first
# WSGI request is handled. This guarantees initialization works under
# Gunicorn/uWSGI (which import the module but don't call main()). The
# initialize_data_sources() function is idempotent-protected by
# data_sources_initialized and data_sources_init_lock.
def _init_on_first_wsgi_request(wsgi_app):
def middleware(environ, start_response):
global data_sources_initialized
if not data_sources_initialized:
with data_sources_init_lock:
if not app.extensions.get("cellxgene_gateway", {}).get("launchtime"):
app.extensions.setdefault("cellxgene_gateway", {})[
"launchtime"
] = current_time_stamp()
if not data_sources_initialized:
initialize_data_sources()
env.validate()
if not item_sources or not len(item_sources):
raise Exception(
"No data sources specified for Cellxgene Gateway"
)
global default_item_source
if default_item_source is None:
default_item_source = item_sources[0]
data_sources_initialized = True
return wsgi_app(environ, start_response)
return middleware
# Wrap the WSGI app so Gunicorn/uWSGI will trigger initialization when the
# first request comes in. Tests that need initialization can call
# initialize_data_sources() directly.
app.wsgi_app = _init_on_first_wsgi_request(app.wsgi_app)
cache = BackendCache()
# Initialize data sources - this is defined later in the file but called here
# to ensure initialization happens when WSGI servers (Gunicorn) import the module
def initialize_data_sources():
"""Initialize data sources from environment variables.
Called at module import time for WSGI server compatibility (Gunicorn).
Uses a guard flag to prevent double initialization within a process."""
global default_item_source
logging.basicConfig(
level=env.log_level,
format="%(asctime)s:%(name)s:%(levelname)s:%(message)s",
)
logger = logging.getLogger(__name__)
cellxgene_data = os.environ.get("CELLXGENE_DATA", None)
cellxgene_bucket = os.environ.get("CELLXGENE_BUCKET", None)
if cellxgene_bucket is not None:
from cellxgene_gateway.items.s3.s3item_source import S3ItemSource
s3_source = S3ItemSource(cellxgene_bucket, name="s3")
item_sources.append(s3_source)
default_item_source = s3_source
logger.info("Initialized S3 data source")
logger.debug(f"S3 bucket: {cellxgene_bucket}")
if cellxgene_data is not None:
from cellxgene_gateway.items.file.fileitem_source import FileItemSource
file_source = FileItemSource(cellxgene_data, name="local")
item_sources.append(file_source)
default_item_source = file_source
logger.info("Initialized local file data source")
logger.debug(f"Data directory: {cellxgene_data}")
if len(item_sources) == 0:
raise Exception("Please specify CELLXGENE_DATA or CELLXGENE_BUCKET")
flask_util.include_source_in_url = len(item_sources) > 1
@app.errorhandler(CellxgeneException)
def handle_invalid_usage(error):
message = f"{error.http_status} Error : {error.message}"
return (
render_template(
"cellxgene_error.html",
extra_scripts=get_extra_scripts(),
message=message,
),
error.http_status,
)
@app.errorhandler(ProcessException)
def handle_invalid_process(error):
message = []
message.append(error.message)
message.append(f"{error.http_status} Error.")
message.append(f"Stdout: {error.stdout}")
message.append(f"Stderr: {error.stderr}")
return (
render_template(
"process_error.html",
extra_scripts=get_extra_scripts(),
message=error.message,
http_status=error.http_status,
stdout=error.stdout,
stderr=error.stderr,
relaunch_url=error.key.relaunch_url(),
annotation_file=error.key.annotation_descriptor,
),
error.http_status,
)
@app.route("/favicon.ico")
def favicon():
return send_from_directory(
os.path.join(app.root_path, "static"),
"nibr.ico",
mimetype="image/vnd.microsof.icon",
)
@app.route("/")
def index():
return render_template(
"index.html",
ip=env.ip,
cellxgene_data=env.cellxgene_data,
extra_scripts=get_extra_scripts(),
)
@app.route("/filecrawl.html")
@app.route("/filecrawl/<path:path>")
def filecrawl(path=None):
source_name = request.args.get("source")
sources = (
filter(
lambda x: x.name == urllib.parse.unquote_plus(source_name),
item_sources,
)
if source_name
else item_sources
)
# loop all data sources --
rendered_sources = [
render_item_source(item_source, path) for item_source in sources
] # will we need to make this async in the page???
rendered_html = "\n".join(rendered_sources)
resp = make_response(
render_template(
"filecrawl.html",
extra_scripts=get_extra_scripts(),
rendered_html=rendered_html,
path=path,
)
)
set_no_cache(resp)
return resp
entry_lock = Lock()
def matching_source(source_name):
if source_name is None and default_item_source is not None:
source_name = default_item_source.name
matching = [i for i in item_sources if i.name == source_name]
if len(matching) != 1:
raise Exception(f"Could not find matching item source {source_name}")
source = matching[0]
return source
@app.route(
"/source/<path:source_name>/view/<path:path>",
methods=["GET", "PUT", "POST"],
)
@app.route("/view/<path:path>", methods=["GET", "PUT", "POST"])
def do_view(path, source_name=None):
source = matching_source(source_name)
match = cache.check_path(source, path)
if match is None:
lookup = source.lookup(path)
if lookup is None:
raise CellxgeneException(
f"Could not find item for path {path} in source {source.name}",
404,
)
key = CacheKey.for_lookup(source, lookup)
print(
f"view path={path}, source_name={source_name}, dataset={key.file_path}, annotation_file= {key.annotation_file_path}, key={key.descriptor}, source={key.source_name}"
)
with entry_lock:
match = cache.check_entry(key)
if match is None:
uascripts = get_extra_scripts()
match = cache.create_entry(key, uascripts)
match.timestamp = current_time_stamp()
if (
match.status == CacheEntryStatus.loaded
or match.status == CacheEntryStatus.loading
):
if source.is_authorized(match.key.descriptor):
return match.serve_content(path)
else:
raise CellxgeneException("User not authorized to access this data", 403)
elif match.status == CacheEntryStatus.error:
raise ProcessException.from_cache_entry(match)
else:
raise CellxgeneException(
f"Unexpected cache entry status {match.status} for key {match.key.descriptor}",
500,
)
@app.route("/cache_status", methods=["GET"])
def do_GET_status():
return render_template(
"cache_status.html",
entry_list=cache.entry_list,
extra_scripts=get_extra_scripts(),
)
@app.route("/cache_status.json", methods=["GET"])
def do_GET_status_json():
def map_entry(entry):
dataset = entry.key.h5ad_item.descriptor
annotation_file = entry.key.annotation_descriptor
return {
"dataset": dataset,
"annotation_file": annotation_file,
"launchtime": entry.launchtime,
"last_access": entry.timestamp,
"status": entry.status.name,
}
return json.dumps(
{
"launchtime": app.extensions.get("cellxgene_gateway", {}).get("launchtime"),
"entry_list": [map_entry(entry) for entry in cache.entry_list],
}
)
def get_cache_key(path):
if request.args.get("source_name"):
source_name = request.args.get("source_name")
elif default_item_source:
source_name = default_item_source.name
else:
source_name = None
source = matching_source(source_name)
key = CacheKey.for_lookup(source, source.lookup(path))
return key
@app.route("/relaunch/<path:path>", methods=["GET"])
def do_relaunch(path):
key = get_cache_key(path)
match = cache.check_entry(key)
if not match is None:
match.terminate()
return redirect(
key.view_url,
code=302,
)
@app.route("/terminate/<path:path>", methods=["GET"])
def do_terminate(path):
key = get_cache_key(path)
match = cache.check_entry(key)
if not match is None:
match.terminate()
return redirect(url_for("do_GET_status"), code=302)
@app.route("/metadata/ip_address", methods=["GET"])
def ip_address():
resp = make_response(env.ip)
return set_no_cache(resp)
def start_pruner_thread():
pruner = PruneProcessCache(cache)
# Run the pruner as a daemon thread so it won't block interpreter
# shutdown (for example when Ctrl-C is used in the main thread).
# This avoids "Exception ignored in: <module 'threading'...>" at exit.
background_thread = Thread(target=pruner, daemon=True)
background_thread.start()
def launch():
start_pruner_thread()
app.extensions.setdefault("cellxgene_gateway", {})[
"launchtime"
] = current_time_stamp()
app.run(host="0.0.0.0", port=env.gateway_port, debug=False)
app.extensions.setdefault("cellxgene_gateway", {})["launchtime"] = None
def main():
"""CLI entry point for Flask development server."""
launch()
if __name__ == "__main__":
main()