diff --git a/server/app/app.py b/server/app/app.py
index 72378caf..3b48d6ea 100644
--- a/server/app/app.py
+++ b/server/app/app.py
@@ -341,9 +341,6 @@ def handle_api_base_url(app, app_config):
     if not api_base_url:
         return
 
-    if api_base_url.endswith("/"):
-        api_base_url = api_base_url[:-1]
-
     sha256 = hashlib.sha256(api_base_url.encode()).hexdigest()
     script_name = f"api_base_url-{sha256}.js"
     script_path = os.path.join(app.root_path, "../common/web/templates", script_name)
diff --git a/server/cli/launch.py b/server/cli/launch.py
index d2a95f2a..d46161d4 100644
--- a/server/cli/launch.py
+++ b/server/cli/launch.py
@@ -296,7 +296,7 @@ class CliLaunchServer(Server):
             "application/octet-stream",
         ]
         Compress(app)
-        if app_config.server_config.app__cors_supports_credentials or app_config.server_config.app__debug:
+        if app_config.server_config.app__debug:
             CORS(app, supports_credentials=True)
 
 
diff --git a/server/common/app_config.py b/server/common/app_config.py
index 487d70bb..3caccec5 100644
--- a/server/common/app_config.py
+++ b/server/common/app_config.py
@@ -435,7 +435,6 @@ class ServerConfig(BaseConfig):
             self.app__generate_cache_control_headers = dc["app"]["generate_cache_control_headers"]
             self.app__server_timing_headers = dc["app"]["server_timing_headers"]
             self.app__csp_directives = dc["app"]["csp_directives"]
-            self.app__cors_supports_credentials = dc["app"]["cors_supports_credentials"]
             self.app__api_base_url = dc["app"]["api_base_url"]
             self.app__web_base_url = dc["app"]["web_base_url"]
 
@@ -506,7 +505,6 @@ class ServerConfig(BaseConfig):
         self.check_attr("app__flask_secret_key", (type(None), str))
         self.check_attr("app__generate_cache_control_headers", bool)
         self.check_attr("app__server_timing_headers", bool)
-        self.check_attr("app__cors_supports_credentials", bool)
         self.check_attr("app__csp_directives", (type(None), dict))
         self.check_attr("app__api_base_url", (type(None), str))
         self.check_attr("app__web_base_url", (type(None), str))
@@ -758,6 +756,8 @@ class ServerConfig(BaseConfig):
     def get_api_base_url(self):
         if self.app__api_base_url == "local":
             return f"http://{self.app__host}:{self.app__port}"
+        if self.app__api_base_url and self.app__api_base_url.endswith("/"):
+            return self.app__api_base_url[:-1]
         return self.app__api_base_url
 
     def get_web_base_url(self):
@@ -765,7 +765,9 @@ class ServerConfig(BaseConfig):
             return f"http://{self.app__host}:{self.app__port}"
         if self.app__web_base_url is None:
             return self.get_api_base_url()
-        return self.app__web_base_url
+        if self.app__web_base_url.endswith("/"):
+            return self.app__web_base_url[:-1]
+        return self.api__web_base_url
 
 
 class DatasetConfig(BaseConfig):
diff --git a/server/common/default_config.py b/server/common/default_config.py
index 3b58322f..16e0c27d 100644
--- a/server/common/default_config.py
+++ b/server/common/default_config.py
@@ -14,11 +14,6 @@ server:
     server_timing_headers: false
     csp_directives: null
 
-    # CORS: Cross Origin Resource Sharing.  If true, this allow users to make
-    # authenticated requests.  This allows cookies and credentials to be submitted
-    # across domains
-    cors_supports_credentials: false
-
     # By default, cellxgene will serve api requests from the same base url as the webpage.
     # In general api_base_url and web_base_url will not need to be set.
     # There are two reasons to set these parameters:
diff --git a/server/eb/app.py b/server/eb/app.py
index 159e6dc4..7a5e834c 100644
--- a/server/eb/app.py
+++ b/server/eb/app.py
@@ -4,10 +4,11 @@ import sys
 import os
 import hashlib
 import base64
+from urllib.parse import urlparse
 from flask import json
 import logging
 from flask_talisman import Talisman
-
+from flask_cors import CORS
 from server.common.aws_secret_utils import handle_config_from_secret
 from server.common.errors import SecretKeyRetrievalError
 
@@ -41,6 +42,14 @@ class WSGIServer(Server):
     def _before_adding_routes(app, app_config):
         script_hashes = WSGIServer.get_csp_hashes(app, app_config)
         server_config = app_config.server_config
+
+        # add the api_base_url to the connect_src csp header.
+        extra_connect_src = []
+        api_base_url = server_config.get_api_base_url()
+        if api_base_url:
+            parse_api_base_url = urlparse(api_base_url)
+            extra_connect_src = [f"{parse_api_base_url.scheme}://{parse_api_base_url.netloc}"]
+
         # This hash should be in sync with the script within
         # `client/configuration/webpack/obsoleteHTMLTemplate.html`
 
@@ -51,7 +60,7 @@ class WSGIServer(Server):
         obsolete_browser_script_hash = ["'sha256-/rmgOi/skq9MpiZxPv6lPb1PNSN+Uf4NaUHO/IjyfwM='"]
         csp = {
             "default-src": ["'self'"],
-            "connect-src": ["'self'"],
+            "connect-src": ["'self'"] + extra_connect_src,
             "script-src": ["'self'", "'unsafe-eval'"]
             + obsolete_browser_script_hash + script_hashes,
             "style-src": ["'self'", "'unsafe-inline'"],
@@ -70,6 +79,13 @@ class WSGIServer(Server):
                     v = [v]
                 csp[k] = csp.get(k, []) + v
 
+        # Add the web_base_url to the CORS header
+        web_base_url = server_config.get_web_base_url()
+        if web_base_url:
+            web_base_url_parse = urlparse(web_base_url)
+            allowed_origin = f"{web_base_url_parse.scheme}://{web_base_url_parse.netloc}"
+            CORS(app, supports_credentials=True, origins=allowed_origin)
+
         Talisman(
             app, force_https=server_config.app__force_https, frame_options="DENY", content_security_policy=csp,
         )