diff --git a/Dockerfile b/Dockerfile
index dd695256..cf6389fa 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -5,6 +5,7 @@ ENV LANG=C.UTF-8
 
 RUN apt-get update && \
     apt-get install -y build-essential libxml2-dev python3-dev python3-pip zlib1g-dev python3-requests python3-aiohttp && \
+    python3 -m pip install --upgrade pip && \
     pip3 install cellxgene
 
 ENTRYPOINT ["cellxgene"]