r524: reverted to bwa-mem end bonus

and reduced the cost of clipping when filtering by identity
This commit is contained in:
Heng Li
2017-10-20 16:57:31 -04:00
parent 15ed0712c2
commit bd04372873
4 changed files with 9 additions and 5 deletions
+5 -1
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@@ -512,7 +512,11 @@ We evaluated minimap2 along with Bowtie2~\citep{Langmead:2012fk}, BWA-MEM and
SNAP~\citep{Zaharia:2011aa}. Minimap2 is 3--4 times as fast as Bowtie2 and
BWA-MEM, but is 1.3 times slower than SNAP. Minimap2 is more accurate on this
simulated data set than Bowtie2 and SNAP but less accurate than BWA-MEM
(Fig.~\ref{fig:eval}b).
(Fig.~\ref{fig:eval}b). Closer investigation reveals that BWA-MEM achieves
a higher accuracy partly because it tries to locally align a read in a small
region close to its mate. If we disable this feature, BWA-MEM becomes slightly
less accurate than minimap2. We might consider to implement a similar heuristic
in minimap2 in future.
\section{Conclusion}