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Haoyu Cheng
2020-01-04 12:11:21 +08:00
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@@ -223,7 +223,7 @@ Note that different species need different assembly graphs. For homozygous genom
the primary assembly contig graph is the best choice.
For species with high heterozygous rate, different haplotypes can be fully separated.
It is important to remove small bubbles from the haplotype-resolved unitig graph. The
reason is that some small bubbles are caused by some somatic mutations or noise in data,
reason is that some small bubbles are caused by somatic mutations or noise in data,
which are not the real haplotype information. In this case, haplotype-resolved processed
unitig graph without small bubbles should be better.
For ordinary human genome, different haplotypes cannot be fully separated due to the low