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variant calling

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chhylp123
2021-04-10 21:58:53 -04:00
parent 3218618bb4
commit 8f733750c4
5 changed files with 789 additions and 115 deletions
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Purge_Dups.cpp
+86 -11
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@@ -2331,7 +2331,7 @@ ma_hit_t_alloc* reverse_sources, long long xBegPos, long long xEndPos)
// fprintf(stderr, "tailIndex->a.n: %u, xReads->n: %u, total_match: %lld, hap_match: %lld, inp_match: %lld\n",
// tailIndex->a.n, xReads->n, (xEndPos - xBegPos + 1), hap_match, inp_match);
return ((double)(inp_match)*1) - ((double)(hap_match-inp_match)*0.334);
return ((double)(inp_match)*CHAIN_MATCH) - ((double)(hap_match-inp_match)*CHAIN_UNMATCH);
}
@@ -5368,6 +5368,88 @@ int max_hang, int min_ovlp, float drop_ratio, p_g_t *pg)
}
void chain_origin_trans_uid_by_purge(hap_overlaps *x, ma_ug_t *ug, hap_cov_t *cov, uint64_t* position_index)
{
uint32_t pri_uid, aux_uid, r_x, r_y;
hap_candidates hap_for, hap_rev, *hap = NULL;
long long x_pos_beg, x_pos_end, y_pos_beg, y_pos_end;
Get_rev(hap_for) = x->rev;
Get_x_beg(hap_for) = x->x_beg_id; Get_x_end(hap_for) = x->x_end_id - 1;
Get_y_beg(hap_for) = x->y_beg_id; Get_y_end(hap_for) = x->y_end_id - 1;
r_x = determine_hap_overlap_type_advance(&hap_for, &(ug->u.a[x->xUid]), &(ug->u.a[x->yUid]),
cov->ruIndex, cov->reverse_sources, cov->coverage_cut, cov->read_g, position_index,
cov->max_hang, cov->min_ovlp, x->xUid, x->yUid, &(cov->u_buffer), &(cov->tailIndex),
&(cov->prevIndex), &x_pos_beg, &x_pos_end, &y_pos_beg, &y_pos_end);
Get_rev(hap_rev) = x->rev;
Get_x_beg(hap_rev) = x->y_beg_id; Get_x_end(hap_rev) = x->y_end_id - 1;
Get_y_beg(hap_rev) = x->x_beg_id; Get_y_end(hap_rev) = x->x_end_id - 1;
r_y = determine_hap_overlap_type_advance(&hap_rev, &(ug->u.a[x->yUid]), &(ug->u.a[x->xUid]),
cov->ruIndex, cov->reverse_sources, cov->coverage_cut, cov->read_g, position_index,
cov->max_hang, cov->min_ovlp, x->yUid, x->xUid, &(cov->u_buffer), &(cov->tailIndex),
&(cov->prevIndex), &x_pos_beg, &x_pos_end, &y_pos_beg, &y_pos_end);
if(r_x == (uint32_t)-1 && r_y == (uint32_t)-1)
{
fprintf(stderr, "ERROR\n");
return;
}
Get_rev(hap_for) = x->rev;
Get_x_beg(hap_for) = x->x_beg_id; Get_x_end(hap_for) = x->x_end_id - 1;
Get_y_beg(hap_for) = x->y_beg_id; Get_y_end(hap_for) = x->y_end_id - 1;
Get_rev(hap_rev) = x->rev;
Get_x_beg(hap_rev) = x->y_beg_id; Get_x_end(hap_rev) = x->y_end_id - 1;
Get_y_beg(hap_rev) = x->x_beg_id; Get_y_end(hap_rev) = x->x_end_id - 1;
if(r_x != (uint32_t)-1 && r_y == (uint32_t)-1)
{
pri_uid = x->xUid; aux_uid = x->yUid; hap = &hap_for;
}
else if(r_x == (uint32_t)-1 && r_y != (uint32_t)-1)
{
aux_uid = x->xUid; pri_uid = x->yUid; hap = &hap_rev;
}
else
{
if(hap_for.score >= hap_rev.score)
{
pri_uid = x->xUid; aux_uid = x->yUid; hap = &hap_for;
}
else
{
aux_uid = x->xUid; pri_uid = x->yUid; hap = &hap_rev;
}
}
determine_hap_overlap_type_advance(hap, &(ug->u.a[pri_uid]), &(ug->u.a[aux_uid]),
cov->ruIndex, cov->reverse_sources, cov->coverage_cut, cov->read_g, position_index,
cov->max_hang, cov->min_ovlp, pri_uid, aux_uid, &(cov->u_buffer), &(cov->tailIndex),
&(cov->prevIndex), &x_pos_beg, &x_pos_end, &y_pos_beg, &y_pos_end);
uint64_t pri_len = ug->u.a[pri_uid].len, aux_len = ug->u.a[aux_uid].len;
pri_uid <<= 1; aux_uid <<= 1; aux_uid += hap->rev;
// uint32_t i_n = cov->t_ch->k_trans.n, i;
chain_origin_trans_uid_by_distance(cov, cov->read_g, &pri_uid, 1, x_pos_beg, &pri_len,
&aux_uid, 1, y_pos_beg, &aux_len, ug, RC_2, hap->score, __func__);
// fprintf(stderr, "\nocc: %u\n", (uint32_t)(cov->t_ch->k_trans.n - i_n));
// fprintf(stderr, "#s-utg%.6ul\t%u\t%u\td-utg%.6ul\t%u\t%u\trev(%u)\n",
// x->xUid+1, x->x_beg_pos, x->x_end_pos, x->yUid+1, x->y_beg_pos, x->y_end_pos, x->rev);
// for (i = i_n; i < cov->t_ch->k_trans.n; i++)
// {
// fprintf(stderr, "s-utg%.6ul\t%u\t%u\td-utg%.6ul\t%u\t%u\trev(%u)\n",
// cov->t_ch->k_trans.a[i].qn+1, cov->t_ch->k_trans.a[i].qs, cov->t_ch->k_trans.a[i].qe,
// cov->t_ch->k_trans.a[i].tn+1, cov->t_ch->k_trans.a[i].ts, cov->t_ch->k_trans.a[i].te,
// cov->t_ch->k_trans.a[i].rev);
// }
}
void collect_purge_trans_cov(ma_ug_t *ug, hap_overlaps_list* ha, hap_cov_t *cov, uint64_t* position_index)
{
uint32_t v, i, k, e, s, o, c_uId, p_uId, x_occ, y_occ;
@@ -5379,17 +5461,10 @@ void collect_purge_trans_cov(ma_ug_t *ug, hap_overlaps_list* ha, hap_cov_t *cov,
for (i = 0; i < ha->x[v].a.n; i++)
{
x = &(ha->x[v].a.a[i]);
/**
get_base_boundary_chain(cov->ruIndex, cov->reverse_sources, cov->coverage_cut,
cov->read_g, position_index, cov->max_hang, cov->min_ovlp, &(ug->u.a[x->xUid]),
&(ug->u.a[x->yUid]), x->xUid, x->yUid, x->x_beg_id, x->x_end_id-1,
x->y_beg_id, x->y_end_id-1, x->rev, &(cov->u_buffer), &(cov->tailIndex),
&(cov->prevIndex));
chain_origin_trans_uid(cov, cov->read_g, RC_2);
**/
if(x->yUid < x->xUid) continue;
chain_origin_trans_uid_by_purge(x, ug, cov, position_index);
q = &(ug->u.a[x->xUid]); s = x->x_beg_id; e = x->x_end_id; o = 0;
for (k = s, p_uId = (uint32_t)-1; k < e; k++)
{