mirror of
https://github.com/chanzuckerberg/cellxgene.git
synced 2026-09-22 03:28:12 +08:00
Better documentation for driver/engines
Removed the REST v2.0 documentation in favor of getting v1.0 working with driver/engine model
This commit is contained in:
+21
-18
@@ -14,18 +14,10 @@ class CXGDriver(metaclass=ABCMeta):
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def _load_or_infer_schema(data):
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pass
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@abstractmethod
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def _set_cell_ids(self):
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pass
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@abstractmethod
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def cells(self):
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pass
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@abstractmethod
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def cellids(self):
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pass
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@abstractmethod
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def genes(self):
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pass
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@@ -34,21 +26,25 @@ class CXGDriver(metaclass=ABCMeta):
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def filter_cells(self, filter):
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"""
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Filter cells from data and return a subset of the data
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A filter is a dictionary where the key is a metadatata category
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Value is dictionary
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value_type: int, float, string
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variable_type: continuous, categorical
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query: filter value, for categorical [val1, val2], for continuous {min: x, max:y}
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Filters are combined with the and operator
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:param filter:
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:return: filtered dataframe
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"""
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pass
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# Should this return the order of metadata fields as the first value?
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@abstractmethod
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def metadata(self, df, fields=None):
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"""
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Generator for metadata. Gets the metadata values cell by cell and returns all value
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or only certain values if names is not None
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Gets metadata key:value for each cells
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:param df: from filter_cells, dataframe
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:param fields: list of keys for metadata to return, returns all metadata values if not set.
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:return: Iterator for cellid + list of cells metadata values ex. [cell-id, val1, val2, val3]
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:return: list of metadata values
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"""
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pass
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@@ -57,7 +53,7 @@ class CXGDriver(metaclass=ABCMeta):
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"""
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Computes a n-d layout for cells through dimensionality reduction.
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:param df: from filter_cells, dataframe
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:return: Iterator for [cellid-1, pos1, pos2], [cellid-2, pos1, pos2]
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:return: [cellid, x, y]
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"""
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pass
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@@ -65,14 +61,21 @@ class CXGDriver(metaclass=ABCMeta):
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def diffexp(self, df1, df2):
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"""
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Computes the top differentially expressed genes between two clusters
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:param df1: First set of cells
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:param df2: Second set of cells
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:return: Up in the air: I recommend [gene name, mean_expression_cells1,
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mean_expression_cells2, average_difference, statistic_value]
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:param df1: from filter_cells, dataframe containing first set of cells
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:param df2: from filter_cells, dataframe containing second set of cells
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:return: top genes, stats and expression values for top genes
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"""
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pass
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@abstractmethod
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def expression(self, df):
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"""
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Retrieves expression for each gene for cells in data frame
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:param df:
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:return: {
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"genes": list of genes,
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"cells": list of cells and expression list,
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"nonzero_gene_count": number of nonzero genes
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}
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"""
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pass
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@@ -52,7 +52,14 @@ class ScanpyEngine(CXGDriver):
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def filter_cells(self, filter):
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"""
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Filter cells from data and return a subset of the data
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A filter is a dictionary where the key is a metadatata category
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Value is dictionary
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value_type: int, float, string
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variable_type: continuous, categorical
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query: filter value, for categorical [val1, val2], for continuous {min: x, max:y}
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Filters are combined with the and operator
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:param filter:
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:return: filtered dataframe
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"""
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cell_idx = np.ones((self.cell_count,), dtype=bool)
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for key, value in filter.items():
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@@ -91,9 +98,11 @@ class ScanpyEngine(CXGDriver):
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def metadata(self, df, fields=None):
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"""
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Generator for metadata. Gets the metadata values cell by cell and returns all value
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or only certain values if names is not None
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Gets metadata key:value for each cells
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:param df: from filter_cells, dataframe
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:param fields: list of keys for metadata to return, returns all metadata values if not set.
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:return: list of metadata values
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"""
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metadata = df.obs.to_dict(orient="records")
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for idx in range(len(metadata)):
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@@ -103,6 +112,8 @@ class ScanpyEngine(CXGDriver):
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def create_graph(self, df):
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"""
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Computes a n-d layout for cells through dimensionality reduction.
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:param df: from filter_cells, dataframe
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:return: [cellid, x, y]
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"""
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getattr(sc.tl, self.graph_method)(df)
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graph = df.obsm["X_{graph_method}".format(graph_method=self.graph_method)]
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@@ -110,6 +121,12 @@ class ScanpyEngine(CXGDriver):
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return np.hstack((df.obs["cell_name"].values.reshape(len(df.obs.index), 1), normalized_graph)).tolist()
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def diffexp(self, cell_list_1, cell_list_2, pval, num_genes):
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"""
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Computes the top differentially expressed genes between two clusters
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:param df1: from filter_cells, dataframe containing first set of cells
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:param df2: from filter_cells, dataframe containing second set of cells
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:return: top genes, stats and expression values for top genes
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"""
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cells_idx_1 = np.in1d(self.data.obs["cell_name"], cell_list_1)
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cells_idx_2 = np.in1d(self.data.obs["cell_name"], cell_list_2)
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expression_1 = self.data.X[cells_idx_1, :]
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@@ -150,8 +167,13 @@ class ScanpyEngine(CXGDriver):
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def expression(self, cells=None, genes=None):
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"""
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Retrieves expression for each gene for cells in data frame
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:param df:
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:return:
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:return: {
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"genes": list of genes,
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"cells": list of cells and expression list,
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"nonzero_gene_count": number of nonzero genes
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}
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"""
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if cells:
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cells_idx = np.in1d(self.data.obs["cell_name"], cells)
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