* initial cut at backed mode
* make flask multithreading conditional on debug flag
* update X access to support backed mode
* lint
* improve help message for backed mode
* fix tests
* add MatrixProxy to normalize supported matrix types
* add FAQ entry for --backed
* remove use of matrix.T
* clean up
* add ability to disable diffexp from CLI; add hueristic to detect likely slow diffexp calculation, and warn user
* fix tests
* do not print diffexp speed warning if diffexp is disabled
* tweak wording of diffexp speed messages
* add FAQ entry on --disable-diffexp
* revise heuristic for warning about slow diffexp
* use quick tooltip delay on diffexp button
* first flatbuffer schema
* do not lint auto-generated files
* add flatbuffers package
* add flatbuffer module
* wire up /data/X/T route
* use flatbuffers for matrix data fetc
* clarity and comments
* add flatbuffer layout route
* clean up obsolete code
* fix tests
* move flake8 config to setup.cfg
* add comments
* lint
* rework layout routes for fbs
* add more type support to fbs
* lint
* add flatbuffer support for annotations
* function name improvements
* fix botched merge with master
* remove unused import
* route cleanup for flatbuffers
* rename function for clarity
* add missing globals to Jest tests
* fix client JS tests
* fix routes for Python tests
* comments for clarity
* non-finite floating point hardening
* more non-finite number handling
* lint
* fix tests for summarizeAnnotations
* harden diffexp calculation against FP errors
* cleanup unused code
* lint
* add encoding tests for flatbuffers
* application type specified as strings
* fix spelling error
* improve variable names
* add note about documentation gap
* rename FBS DataFrame to Matrix
* add cutoff for low expression genes in topN selection
* remove debugging printfs
* change cli param name for diffexp cutoff
* change CLI param name
* second try at diffexp - using lfc sort with pval cutoff
* use lfc cutoff
* update comments to match code; cap p-value adjustment to max of 1
* lint
* explain diffexp in readme
* add link
* add diffexp-lfc-cutoff to test config
* update test to match revised diffexp spec
* fix latent bug in GET arg handling that was breaking tests
* lint
* comment cleanup
* fix variance overestimation so it is symmetric
* lint
* new diffexp REST API spec
* new diffexp REST API; faster diffexp and dataframe slicing
* first draft of fast diffexp
* convert variance calculation to two-pass method
* lint
* update front-end use of API
* fix typo in spec
* disable content compression
* catch index filter format errors
* clean up of dead code
* resolve PR review comments
